Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

Santiago, Jon‐Jon; L. Dangerfield, Aran; G. Rattan, Sunil; L. Bathe, Krista; H. Cunnington, Ryan; E. Raizman, Joshua; M. Bedosky, Kristen; H. Freed, Darren; Kardami, Elissavet; M.C. Dixon, Ian

doi:10.1002/dvdy.22280

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Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

Shared by NobleBlocks on May 17, 2010 • 12:00 AM UTC

Authors:

Jon‐Jon Santiago

Aran L. Dangerfield

Sunil G. Rattan

Abstract

Abstract In fibrosing hearts, myofibroblasts are associated with cardiac extracellular matrix remodeling. Expression of key genes in the transition of cardiac fibroblast to myofibroblast phenotype in post‐myocardial infarction heart and in vitro has not been well addressed. Contractile, focal adhesi...

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