Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A

The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT. A high-affinity calcineurin-binding peptide was selected from combinat... View More