Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamäki, Kristiina; Lappalainen, Jani; Öörni, Katariina; Välimäki, Elina; Matikainen, Sampsa; T. Kovanen, Petri; K. Eklund, Kari

doi:10.1371/journal.pone.0011765

Public

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Published in PLoS ONE • Jul 23, 2010

Authors:

Kristiina Rajamäki

Jani Lappalainen

Katariina Öörni

Abstract

BACKGROUND: Chronic inflammation of the arterial wall is a key element in the pathogenesis of atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive. Inflammasomes are cytoplasmic caspase-1-activating protein complexes that promote maturation and secretion of the p...

Subject

Inflammasome

Inflammation

Secretion

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!