K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

Khuong-Quang, Dong-Anh; Buczkowicz, Pawel; Rakopoulos, Patricia; Liu, Xiao-Yang; M. Fontebasso, Adam; Bouffet, Éric; Bartels, Ute; Albrecht, Steffen; Schwartzentruber, Jeremy; Létourneau, Louis; Bourgey, Mathieu; Bourque, Guillaume; Montpetit, Alexandre; Bourret, Geneviève; Lepage, Pierre; Fleming, Adam; Lichter, Peter; Kool, Marcel; von Deimling, Andreas; Sturm, Dominik; Korshunov, Andrey; Faury, Damien; Jones, David; Majewski, Jacek; M. Pfister, Stefan; Jabado, Nada; Hawkins, Cynthia

doi:10.1007/s00401-012-0998-0

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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

Published in Acta Neuropathologica • Jun 3, 2012

Authors:

Dong-Anh Khuong-Quang

Pawel Buczkowicz

Patricia Rakopoulos

Abstract

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3....

Subject

ATRX

Histone H3

Mutation

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