Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages

Choi, Hosoon; Hwa Lee, Ryang; Bazhanov, Nikolay; Youn Oh, Joo; J. Prockop, Darwin

doi:10.1182/blood-2010-12-327353

Public

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages

Published in Blood • May 7, 2011

Authors:

Hosoon Choi

Ryang Hwa Lee

Nikolay Bazhanov

Abstract

Human mesenchymal stem/progenitor cells (hMSCs) repair tissues and modulate immune systems but the mechanisms are not fully understood. We demonstrated that hMSCs are activated by inflammatory signals to secrete the anti-inflammatory protein, TNF-α-stimulated gene 6 protein (TSG-6) and thereby creat...

Subject

Inflammation

Zymosan

Cell biology

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