Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

G. Ramírez, Belén; Blázquez, Cristina; Gómez del Pulgar, Teresa; Guzmán, Manuel; L. de Ceballos, Marı́a

doi:10.1523/jneurosci.4540-04.2005

Public

Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

Published in Journal of Neuroscience • Feb 23, 2005

Authors:

Belén G. Ramírez

Cristina Blázquez

Teresa Gómez del Pulgar

Abstract

Alzheimer's disease (AD) is characterized by enhanced beta-amyloid peptide (betaA) deposition along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits. Cannabinoids are neuroprotective agents against excitotoxicity in vitro and acute brain damage in vivo. This b...

Subject

Neuroprotection

Cannabinoid

Microglia

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