Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism

Gouédard, Cédric; Barouki, Robert; Morel, Yannick

doi:10.1128/mcb.24.12.5209-5222.2004

Public

Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism

Published in Molecular and Cellular Biology • May 28, 2004

Authors:

Cédric Gouédard

Robert Barouki

Yannick Morel

Abstract

Human paraoxonase 1 (PON-1) is a serum high-density lipoprotein-associated enzyme mainly secreted by the liver. It has endogenous and exogenous substrates and displays protective properties with respect to cardiovascular disease and organophosphate intoxication. In the HuH7 human hepatoma cell line,...

Subject

Aryl hydrocarbon receptor

Biology

Molecular biology

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