Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

B. Nankova, Bistra; Agarwal, Raj; F. MacFabe, Derrick; F. La Gamma, Edmund

doi:10.1371/journal.pone.0103740

Public

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Published in PLoS ONE • Aug 29, 2014

Authors:

Bistra B. Nankova

Raj Agarwal

Derrick F. MacFabe

Abstract

Alterations in gut microbiome composition have an emerging role in health and disease including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA), and butyric acid (BA), which are present in diet and are fermentation products of many gastrointestinal bacteria, are show...

Subject

Gene expression

Biology

Reporter gene

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