Single-dose and multiple-dose pharmacokinetics and dose proportionality of intravenous and intramuscular HPβCD-diclofenac (Dyloject) compared with other diclofenac formulations.

F, Mermelstein; DA, Hamilton; C, Wright; PG, Lacouture; A, Ramaiya; DB, Carr

doi:10.1002/phar.1304

Public

Single-dose and multiple-dose pharmacokinetics and dose proportionality of intravenous and intramuscular HPβCD-diclofenac (Dyloject) compared with other diclofenac formulations.

Shared by NobleBlocks on Jun 6, 2013 • 12:00 AM UTC

Authors:

Mermelstein F

Hamilton DA

Wright C

Abstract

Study objective To evaluate single- and repeated-dose pharmacokinetics (PK) and dose proportionality of hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac compared with Voltarol after intravenous (IV) and intramuscular (IM) administration.Design Study 1: Single-dose randomized four-way crossover study....

Subject

Analgesia

Pharmacokinetics

Intravenous

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