Single‐Dose and Multiple‐Dose Pharmacokinetics and Dose Proportionality of Intravenous and Intramuscular <scp>HP</scp> β <scp>CD</scp> ‐Diclofenac (Dyloject) Compared with Other Diclofenac Formulations

Mermelstein, Fred; A. Hamilton, Douglas; Wright, Curtis; G. Lacouture, Peter; Ramaiya, Atulkumar; B. Carr, Daniel

doi:10.1002/phar.1304

Public

Single‐Dose and Multiple‐Dose Pharmacokinetics and Dose Proportionality of Intravenous and Intramuscular HP β CD ‐Diclofenac (Dyloject) Compared with Other Diclofenac Formulations

Published in Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy • Jun 6, 2013

Authors:

Fred Mermelstein

Douglas A. Hamilton

Curtis Wright

Abstract

STUDY OBJECTIVE: To evaluate single- and repeated-dose pharmacokinetics (PK) and dose proportionality of hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac compared with Voltarol after intravenous (IV) and intramuscular (IM) administration. DESIGN: Study 1: Single-dose randomized four-way crossover stu...

Subject

Diclofenac

Pharmacokinetics

Cmax

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