Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

Yau, Suk‐Yu; Li, Ang; L.C. Hoo, Ruby; Pang Ching, Yick; R. Christie, Brian; M.C. Lee, Tatia; Xu, Aimin; So, Kwok‐Fai

doi:10.1073/pnas.1415219111

Public

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

Published in Proceedings of the National Academy of Sciences • Oct 20, 2014

Authors:

Suk‐Yu Yau

Ang Li

Ruby L.C. Hoo

Abstract

Adiponectin (ADN) is an adipocyte-secreted protein with insulin-sensitizing, antidiabetic, antiinflammatory, and antiatherogenic properties. Evidence is also accumulating that ADN has neuroprotective activities, yet the underlying mechanism remains elusive. Here we show that ADN could pass through t...

Subject

Neurogenesis

Hippocampal formation

Adiponectin

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