Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation

Cursiefen, Claus; Viaud, Eric; Bock, Felix; Geudelin, Bernard; Ferry, Antoine; Kadlecová, Pavla; Lévy, Michel; Al Mahmood, Salman; Colin, Sylvie; Thorin, Éric; Majo, F.; E. Frueh, Béatrice; Wilhelm, Frank; Meyer‐ter‐Vehn, Tobias; Geerling, Gerd; Böhringer, Daniel; Reinhard, Thomas; Meller, Daniel; Pleyer, Uwe; Bachmann, Björn; Seitz, Berthold

doi:10.1016/j.ophtha.2014.03.038

Public

Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation

Published in Ophthalmology • May 6, 2014

Authors:

Claus Cursiefen

Eric Viaud

Felix Bock

Abstract

ObjectiveEye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results in a phase III study and investigated a potential clinical benefit on vi...

Subject

Medicine

Corneal neovascularization

Transplantation

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