Evidence that a neutrophil–keratinocyte crosstalk is an early target of
                    <scp>IL</scp>
                    ‐17A inhibition in psoriasis

Reich, Kristian; A. Papp, Kim; T. Matheson, Robert; H. Tu, John; Bissonnette, Robert; Bourcier, Marc; Gratton, David; A. Kunynetz, Rodion; Poulin, Yves; A. Rosoph, Les; Stingl, Georg; M. Bauer, Wolfgang; M. Salter, Janeen; M. Falk, Thomas; A. Blödorn‐Schlicht, Norbert; Hueber, Wolfgang; Sommer, Ulrike; M. Schumacher, Martin; Peters, Thomas; Kriehuber, Ernst; M. Lee, David; A. Wieczorek, Grazyna; Kolbinger, Frank; C. Bleul, Conrad

doi:10.1111/exd.12710

Public

Evidence that a neutrophil–keratinocyte crosstalk is an early target of IL ‐17A inhibition in psoriasis

Shared by NobleBlocks on May 8, 2015 • 12:00 AM UTC

Authors:

Kristian Reich

Kim A. Papp

Robert T. Matheson

Abstract

Abstract The response of psoriasis to antibodies targeting the interleukin ( IL )‐23/ IL ‐17A pathway suggests a prominent role of T‐helper type‐17 (Th17) cells in this disease. We examined the clinical and immunological response patterns of 100 subjects with moderate‐to‐severe psoriasis receiving 3...

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