RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

O. Ebinu, Julius; A. Bottorff, Drell; Y. W. Chan, Edmond; L. Stang, Stacey; J. Dunn, Robert; C. Stone, James

doi:10.1126/science.280.5366.1082

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RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

Shared by NobleBlocks on May 15, 1998 • 12:00 AM UTC

Authors:

Julius O. Ebinu

Drell A. Bottorff

Edmond Y. W. Chan

Abstract

RasGRP, a guanyl nucleotide–releasing protein for the small guanosine triphosphatase Ras, was characterized. Besides the catalytic domain, RasGRP has an atypical pair of “EF hands” that bind calcium and a diacylglycerol (DAG)-binding domain. RasGRP activated Ras and caused transformation in fibrobla...

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