Association of Type and Location of<i>BRCA1</i>and<i>BRCA2</i>Mutations With Risk of Breast and Ovarian Cancer

R. Rebbeck, Timothy; Mitra, Nandita; Wan, Fei; M. Sinilnikova, Olga; Healey, Sue; McGuffog, Lesley; Mazoyer, Sylvie; Chenevix‐Trench, Georgia; F. Easton, Douglas; C. Antoniou, Antonis; L. Nathanson, Katherine; Laitman, Yael; Kushnir, Anya; Paluch–Shimon, Shani; Berger, Raanan; Zidan, Jamal; Friedman, Eitan; Ehrencrona, Hans; Stenmark‐Askmalm, Marie; Einbeigi, Zakaria; Loman, Niklas; Harbst, Katja; Rantala, Johanna; Melin, Beatrice; Huo, Dezheng; I. Olopade, Olufunmilayo; Seldon, Joyce; A. Ganz, Patricia; L. Nussbaum, Robert; Chan, Salina; Odunsi, Kunle; A. Gayther, Simon; M. Domchek, Susan; Arun, Banu; H. Lu, Karen; Mitchell, Gillian; Y. Karlan, Beth; Walsh, Christine; Lester, Jenny; K. Godwin, Andrew; B. Pathak, Harsh; A. Ross, Eric; B. Daly, Mary; S. Whittemore, Alice; M. John, Esther; Miron, Alexander; Beth Terry, Mary; K. Chung, Wendy; E. Goldgar, David; S. Buys, Saundra; Janavičius, Ramūnas; Tihomirova, Laima; Tung, Nadine; M. Dorfling, Cecilia; J. van Rensburg, Elizabeth; Steele, Linda; L. Neuhausen, Susan; Chun Ding, Yuan; Ejlertsen, Bent; Gerdes, Anne‐Marie; van Overeem Hansen, Thomas; Ramón y Cajal, Teresa; Osório, Ana; Benı́tez, Javier; Godino, Javier; Tejada, María‐Isabel; Durán, M.; N. Weitzel, Jeffrey; Bobolis, Kristie; Sand, Sharon; Campbell Fontaine, Annette; Savarese, Antonella; Pasini, Barbara; Peissel, Bernard; Bonanni, Bernardo; Zaffaroni, Daniela; Vignolo-Lutati, Francesca; Scuvera, Giulietta; Giannini, Giuseppe; Bernard, Loris; Genuardi, Maurizio; Radice, Paolo; Dolcetti, Riccardo; Manoukian, Siranoush; Pensotti, Valeria; Gismondi, Viviana; Yannoukakos, Drakoulis; Fostira, Florentia; E. Garber, Judy; Torres, Diana; Usman Rashid, Muhammad; Hamann, Ute; Peock, Susan; Frost, Debra; Platte, Radka; Gareth Evans, D.; A. Eeles, Rosalind; Davidson, Rosemarie; Eccles, Diana; Cole, Trevor; Cook, Jackie; Brewer, Carole; Hodgson, Shirley; J. Morrison, Patrick; Walker, Lisa; Porteous, Mary; John Kennedy, M.; Izatt, Louise; Adlard, Julian; Donaldson, Alan; Ellis, Steve; Sharma, Priyanka; K. Schmutzler, Rita; Wappenschmidt, Barbara; Becker, Alexandra; Rhiem, Kerstin; Hahnen, Eric; Engel, Christoph; Meindl, Alfons; Engert, Stefanie; Ditsch, Nina; Arnold, Norbert; Jörg Plendl, Hans; Mundhenke, Christoph; Niederacher, Dieter; C. Fleisch, Markus; Sutter, Christian; R. Bartram, Claus; Dikow, Nicola; Wang‐Gohrke, Shan; Gadzicki, Dorothea; Steinemann, Doris; Kast, Karin; de Beer, Marit; Varon-Mateeva, Raymonda; Gehrig, Andrea; H. F. Weber, Bernhard; Stoppa‐Lyonnet, Dominique; M. Sinilnikova, Olga; Mazoyer, Sylvie; Houdayer, Claude; Belotti, Muriel; Gauthier‐Villars, Marion; Damiola, Francesca; Boutry‐Kryza, Nadia; Lasset, Christine; Sobol, Hagay; Peyrat, Jean‐Philippe; Muller, Danièle; Fricker, Jean‐Pierre; Collonge‐Rame, Marie‐Agnès; Mortemousque, Isabelle; Noguès, Catherine; Rouleau, Étienne; Isaacs, Claudine; De Paepe, Anne; Poppe, Bruce; Claes, Kathleen; De Leeneer, Kim; Piedmonte, Marion; C. Rodriguez, Gustavo; Wakely, Katie; F. Boggess, John; V. Blank, Stephanie; Basil, Jack; Azodi, Masoud; Phillips, Kelly‐Anne; Caldés, Trinidad; de la Hoya, Miguel; Romero, Atocha; Nevanlinna, Heli; Aittomäki, Kristiina; H. van der Hout, Annemarie; B.L. Hogervorst, Frans; Verhoef, Senno; Margriet Collée, J.; Seynaeve, Caroline; C. Oosterwijk, Jan; J. P. Gille, Johannes; Wijnen, Juul; Gómez, E.; M. Kets, Carolien; G.E.M. Ausems, Margreet; M. Aalfs, Cora; Devilee, Peter; R. Mensenkamp, Arjen; Kwong, Ava; Oláh, Edith; Papp, J.; Dı́ez, Orland; Lázaro, Conxi; Darder, Esther; Blanco, Ignacio; Salinas, Mónica; Jakubowska, Anna; Lubiński, Jan; Gronwald, Jacek; Jaworska–Bieniek, Katarzyna; Durda, Katarzyna; Sukiennicki, Grzegorz; Huzarski, Tomasz; Byrski, Tomasz; Cybulski, Cezary; Tołoczko‐Grabarek, Aleksandra; Złowocka-Perłowska, Elżbieta; Menkiszak, Janusz; Arason, Aðalgeir; B. Barkardóttir, Rósa; Simard, Jacques; Laframboise, Rachel; Montagna, Marco; Agata, Simona; Alducci, Elisa; Peixoto, Ana; R. Teixeira, Manuel; B. Spurdle, Amanda; Hyuk Lee, Min; K. Park, Sue; Kim, Sung-Won; M. Friebel, Tara; J. Couch, Fergus; M. Lindor, Noralane; Shane Pankratz, V.; Guidugli, Lucia; Wang, Xianshu; Tischkowitz, Marc; Foretová, Lenka; Vijai, Joseph; Offit, Kenneth; E. Robson, Mark; Rau‐Murthy, Rohini; D. Kauff, Noah; Fink-Retter, A.; F. Singer, Christian; Rappaport, Christine; Gschwantler‐Kaulich, Daphne; Pfeiler, Georg; M. Tea, Muy‐Kheng; Berger, Andreas; H. Greene, Mark; L. Mai, Phuong; N. Imyanitov, Evgeny; E. Toland, Amanda; Senter, Leigha; Bojesen, Anders; Søkilde Pedersen, Inge; Skytte, Anne‐Bine; Sunde, Lone; Thomassen, Mads; Traasdahl Moeller, Sanne; A. Kruse, Torben; Birk Jensen, Uffe; A. Caligo, Maria; Aretini, Paolo; Teo, Soo‐Hwang; G. Selkirk, Christina; J. Hulick, Peter; L. Andrulis, Irene

doi:10.1001/jama.2014.5985

Public

Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer

Published in JAMA • Apr 7, 2015

Authors:

Timothy R. Rebbeck

Nandita Mitra

Fei Wan

Abstract

IMPORTANCE: Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE: To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN, SETTING, AND PARTICIPANTS: Observational study of women who were ascertained be...

Subject

Ovarian cancer

Breast cancer

Medicine

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