CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

D. Wright, Samuel; Ramos, Robert; S. Tobias, Peter; J. Ulevitch, Richard; C. Mathison, John

doi:10.1126/science.1698311

Public

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Published in Science • Sep 21, 1990

Authors:

Samuel D. Wright

Robert Ramos

Peter S. Tobias

Abstract

Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-alpha (TNF-alpha). Excess secretion of TNF-alpha causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds t...

Subject

Lipopolysaccharide binding protein

CD14

Lipopolysaccharide

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