CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

D. Wright, Samuel; A. Ramos, Robert; S. Tobias, Peter; J. Ulevitch, Richard; C. Mathison, John

doi:10.1126/science.1698311

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Shared by NobleBlocks on Sep 21, 1990 • 12:00 AM UTC

Authors:

Samuel D. Wright

Robert A. Ramos

Peter S. Tobias

Abstract

Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-α (TNF-α). Excess secretion of TNF-α causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds to the serum ...

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