A Novel Method for Direct Site-Specific Radiolabeling of Peptides Using [18F]FDG

Namavari, Mohammad; Cheng, Zhen; Zhang, Rong; De, Abhijit; Levi, Jelena; K. Hoerner, Joshua; Yaghoubi, Shahriar; A. Syud, Faisal; S. Gambhir, Sanjiv

doi:10.1021/bc800422b

Public

A Novel Method for Direct Site-Specific Radiolabeling of Peptides Using [18F]FDG

Published in Bioconjugate Chemistry • Feb 18, 2009

Authors:

Mohammad Namavari

Zhen Cheng

Rong Zhang

Abstract

We have used the well-accepted and easily available 2-[(18)F]fluoro-2-deoxyglucose ([(18)F]FDG) positron emission tomography (PET) tracer as a prosthetic group for synthesis of (18)F-labeled peptides. We herein report the synthesis of [(18)F]FDG-RGD ((18)F labeled linear RGD) and [(18)F]FDG-cyclo(RG...

Subject

Chemistry

Radiosynthesis

Radioligand

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