Micro RNA ‐122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β ‐catenin pathway

Xu, Jie; Zhu, Xiuming; Wu, Lingjiao; Yang, Rong; Yang, Zeran; Wang, Qiangfeng; Wu, Fusheng

doi:10.1111/j.1478-3231.2011.02750.x

Public

Micro RNA ‐122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β ‐catenin pathway

Published in Liver International • Jan 26, 2012

Authors:

Jie Xu

Xiuming Zhu

Lingjiao Wu

Abstract

AIMS: To validate whether the anti-cancer effect of microRNA-122 (miR-122) on hepatocellular carcinoma (HCC) is mediated through regulating Wnt/β-catenin signalling pathways. METHODS: The expression levels of miR-122 in HCC tissues and varied hepatoma cells were quantified by real-time PCR. MiR-122 ...

Subject

MiR-122

Wnt signaling pathway

Apoptosis

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