Abstract 2876: Inflammation of the tumor microenvironment is regulated by myeloid derived suppressor cell and macrophage crosstalk.

W. Beury, Daniel; H. Parker, Katherine; Ostrand‐Rosenberg, Suzanne

doi:10.1158/1538-7445.am2013-2876

Public

Abstract 2876: Inflammation of the tumor microenvironment is regulated by myeloid derived suppressor cell and macrophage crosstalk.

Published in Cancer Research • Apr 1, 2013

Authors:

Daniel W. Beury

Katherine H. Parker

Suzanne Ostrand‐Rosenberg

Abstract

Abstract Myeloid-Derived Suppressor Cells (MDSC) polarize macrophages to a Type II tumor-promoting phenotype via MDSC-macrophage crosstalk. We previously demonstrated that MDSC produce IL-10 which inhibits macrophage production of IL-12, and MDSC production of IL-10 is dependent on TLR4 and enhanced...

Subject

Myeloid-derived Suppressor Cell

Inflammation

Cytokine

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