Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

T, Ebisawa; M, Fukuchi; G, Murakami; T, Chiba; K, Tanaka; T, Imamura; K, Miyazono

doi:10.1074/jbc.c100008200

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

Shared by NobleBlocks on Feb 13, 2001 • 12:00 AM UTC

Authors:

Ebisawa T

Fukuchi M

Murakami G

Abstract

Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins. Smad7 is induced by TGF-beta, stably interacts with activated TGF-beta type I receptor (TbetaR-I), and interferes with the phosphorylation of receptor-re...

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