Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

Ebisawa, Takanori; Fukuchi, Minoru; Murakami, Gyo; Chiba, Tomoki; Tanaka, Keiji; Imamura, Takeshi; Miyazono, Kohei

doi:10.1074/jbc.c100008200

Public

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

Published in Journal of Biological Chemistry • Apr 1, 2001

Authors:

Takanori Ebisawa

Minoru Fukuchi

Gyo Murakami

Abstract

Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins. Smad7 is induced by TGF-beta, stably interacts with activated TGF-beta type I receptor (TbetaR-I), and interferes with the phosphorylation of receptor-re...

Subject

Degradation (telecommunications)

Receptor

Transforming growth factor

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