Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

Lenz, Georg; W. Wright, George; C. Tolga Emre, N.; Kohlhammer, Holger; S. Davé, Sandeep; Eric Davis, R.; A. Carty, Shannon; T. Lam, Lloyd; L. Shaffer, Arthur; Xiao, Wenming; Powell, John; Rosenwald, Andreas; Ott, German; Konrad Müller‐Hermelink, Hans; D. Gascoyne, Randy; M. Connors, Joseph; Campo, Elı́as; S. Jaffe, Elaine; Delabie, Jan; B. Smeland, Erlend; M. Rimsza, Lisa; I. Fisher, Richard; D. Weisenburger, Dennis; C. Chan, Wing; M. Staudt, Louis

doi:10.1073/pnas.0804295105

Public

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

Published in Proceedings of the National Academy of Sciences • Sep 2, 2008

Authors:

Georg Lenz

George W. Wright

N. C. Tolga Emre

Abstract

Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by dis...

Subject

Diffuse large B-cell lymphoma

Biology

Cancer research

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