<i>TERT</i>
                    Promoter Mutations in Familial and Sporadic Melanoma

Horn, Susanne; Figl, Adina; Sivaramakrishna Rachakonda, P.; Fischer, Christine; Sucker, Antje; Gast, Andreas; Kadel, Stephanie; Moll, Iris; Nagore, Eduardo; Hemminki, Kari; Schadendorf, Dirk; Kumar, Rajiv

doi:10.1126/science.1230062

Public

TERT Promoter Mutations in Familial and Sporadic Melanoma

Shared by NobleBlocks on Feb 22, 2013 • 12:00 AM UTC

Authors:

Susanne Horn

Adina Figl

P. Sivaramakrishna Rachakonda

Abstract

Promoter Mutations and Cancer Cancer genome sequencing projects have highlighted the pathogenic role of recurrent mutations within the protein-coding regions of genes. Now, two studies suggest that the scope of mutations in human tumors extends to gene regulatory regions. In a study of 70 melanomas,...

Discussions