Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.

Sato, Hiroyasu; Kato, Rina; Isogai, Yuki; Saka, Go-ichi; Ohtsuki, Mitsuhiro; Taketomi, Yoshitaka; Yamamoto, Kei; Tsutsumi, Kae; Yamada, Joe; Masuda, Seiko; Ishikawa, Yukio; Ishii, Toshiharu; Kobayashi, Tetsuyuki; Ikeda, Kazutaka; Taguchi, Ryo; Hatakeyama, Shinji; Hara, Shuntaro; Kudo, Ichiro; Itabe, Hiroyuki; Murakami, Makoto

doi:10.1074/jbc.m804628200

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Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.

Shared by NobleBlocks on Nov 28, 2008 • 12:00 AM UTC

Authors:

Hiroyasu Sato

Rina Kato

Yuki Isogai

Abstract

Among the many mammalian secreted phospholipase A2 (sPLA2) enzymes, PLA2G3 (group III secreted phospholipase A2) is unique in that it possesses unusual N- and C-terminal domains and in that its central sPLA2 domain is homologous to bee venom PLA2 rather than to other mammalian sPLA2s. To elucidate t...

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