Additional copies of a 25 Mb chromosomal region originating from 17q23.1-17qter are present in 90% of high-grade neuroblastomas

Meddeb, Mounira; Danglot, Gisèle; Chudoba, Iise; Vénuat, Anne‐Marie; Bénard, Jean; Avet‐Loiseau, Hervé; Vasseur, Béatrice; Le Paslier, Denis; Terrier‐Lacombe, Marie‐José; Hartmann, Olivier; Bernheim, Alain

doi:10.1002/(sici)1098-2264(199611)17:3<156::aid-gcc3>3.0.co;2-3

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Additional copies of a 25 Mb chromosomal region originating from 17q23.1-17qter are present in 90% of high-grade neuroblastomas

Published in Genes Chromosomes and Cancer • Nov 1, 1996

Authors:

Mounira Meddeb

Gisèle Danglot

Iise Chudoba

Abstract

Neuroblastoma shows remarkable heterogeneity, ranging from spontaneous regression to progression toward highly malignant tumors. In search of genetic abnormalities that could explain this variability, we have characterized neuroblastoma tumors by using multiple fluorescent hybridizations. Our result...

Subject

Neuroblastoma

Chromosomal translocation

Biology

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