Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus.

N, Luplertlop; P, Surasombatpattana; S, Patramool; E, Dumas; L, Wasinpiyamongkol; L, Saune; R, Hamel; E, Bernard; D, Sereno; F, Thomas; D, Piquemal; H, Yssel; L, Briant; D, Missé

doi:10.1371/journal.ppat.1001252

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Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus.

Shared by NobleBlocks on Jan 13, 2011 • 12:00 AM UTC

Authors:

Luplertlop N

Surasombatpattana P

Patramool S

Abstract

The ultimate stage of the transmission of Dengue Virus (DENV) to man is strongly dependent on crosstalk between the virus and the immune system of its vector Aedes aegypti (Ae. aegypti). Infection of the mosquito's salivary glands by DENV is the final step prior to viral transmission. Therefore, in ...

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