Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

Sierro, Frédéric; Biben, Christine; Martínez‐Muñoz, Laura; Mellado, Mario; M. Ransohoff, Richard; Li, Meizhang; Woehl, Blanche; Leung, Helen; R. Groom, Joanna; Batten, Marcel; P. Harvey, Richard; Martínez‐A, Carlos; R. Mackay, Charles; Mackay, Fabienne

doi:10.1073/pnas.0702229104

Public

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

Published in Proceedings of the National Academy of Sciences • Sep 5, 2007

Authors:

Frédéric Sierro

Christine Biben

Laura Martínez‐Muñoz

Abstract

Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B cells, a cell type associated with autoimmune diseases. W...

Subject

Biology

Cell biology

Chemokine

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