Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

del Peso, Luis; González-Garcı́a, Maribel; Page, Carmen; Herrera, Román; Núñez, Gabriel

doi:10.1126/science.278.5338.687

Public

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

Published in Science • Oct 24, 1997

Authors:

Luis del Peso

Maribel González-Garcı́a

Carmen Page

Abstract

BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation induced by interleukin-3 (IL-3) was inhibited by specific inhibitors of phosphoinositide 3-kinase (PI 3-kinase). Akt, a survival-promoting serine-threonine protein kinase, ...

Subject

Protein kinase B

Phosphorylation

Kinase

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