Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

Akhmetshina, Alfiya; Dees, Clara; Pileckytė, Margarita; Maurer, Britta; Axmann, Roland; Jüngel, Astrid; Zwerina, Jochen; Gay, Steffen; Schett, Georg; Distler, Oliver; H. W. Distler, Jörg

doi:10.1096/fj.07-105627

Public

Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

Published in The FASEB Journal • Mar 7, 2008

Authors:

Alfiya Akhmetshina

Clara Dees

Margarita Pileckytė

Abstract

ABSTRACT Abelson kinase (c‐abl) and platelet‐derived growth factor (PDGF) are key players in the pathogenesis of systemic sclerosis (SSc). The aim of the present study was to evaluate the antifibrotic potential of dasatinib and nilotinib, 2 novel inhibitors of c‐abl and PDGF, which are well tolerate...

Subject

Nilotinib

Dasatinib

Pharmacology

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