Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

Maria Spaggiari, Grazia; Capobianco, Andrea; Abdelrazik, Heba; Becchetti, Flavio; Cristina Mingari, Maria; Moretta, Lorenzo

doi:10.1182/blood-2007-02-074997

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Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

Grazia Maria Spaggiari

Andrea Capobianco

Heba Abdelrazik

Abstract

Abstract Recently, a number of clinical trials used either mesenchymal stem cells (MSCs) or natural killer (NK) cells in an attempt to improve the effectiveness of hematopoietic stem cell transplantation (HSCT). In view of the relevant role of both MSCs and NK cells in HSCT, we have recently explore...

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