Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

Maria Spaggiari, Grazia; Capobianco, Andrea; Abdelrazik, Heba; Becchetti, Flavio; Cristina Mingari, Maria; Moretta, Lorenzo

doi:10.1182/blood-2007-02-074997

Public

Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

Published in Blood • Oct 19, 2007

Authors:

Grazia Maria Spaggiari

Andrea Capobianco

Heba Abdelrazik

Abstract

Recently, a number of clinical trials used either mesenchymal stem cells (MSCs) or natural killer (NK) cells in an attempt to improve the effectiveness of hematopoietic stem cell transplantation (HSCT). In view of the relevant role of both MSCs and NK cells in HSCT, we have recently explored the res...

Subject

Mesenchymal stem cell

Lymphokine-activated killer cell

Indoleamine 2

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