Alendronate for the Treatment of Pediatric Osteogenesis Imperfecta: A Randomized Placebo-Controlled Study

M. Ward, Leanne; Rauch, Frank; P. Whyte, Michael; DʼAstous, Jacques; E. Gates, Phillip; P. Grogan, Dennis; L. Lester, Edward; E. McCall, Richard; A. Pressly, Thomas; O. Sanders, James; A. Smith, Peter; D. Steiner, Robert; Sullivan, Elroy; H. Tyerman, Gayle; L. Smith-Wright, D.; Verbruggen, Nadia; Heyden, Norman; Lombardi, Assunta; H. Glorieux, F.

doi:10.1210/jc.2010-0636

Public

Alendronate for the Treatment of Pediatric Osteogenesis Imperfecta: A Randomized Placebo-Controlled Study

Published in The Journal of Clinical Endocrinology & Metabolism • Nov 25, 2010

Authors:

Leanne M. Ward

Frank Rauch

Michael P. Whyte

Abstract

CONTEXT: Information on the use of oral bisphosphonate agents to treat pediatric osteogenesis imperfecta (OI) is limited. OBJECTIVE: The objective of the investigation was to study the efficacy and safety of daily oral alendronate (ALN) in children with OI. DESIGN AND PARTICIPANTS: We conducted a mu...

Subject

Medicine

Placebo

Osteogenesis imperfecta

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