A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

Haruta, Tetsuro; Uno, Tatsuhito; Kawahara, Junko; Takano, Atsuko; Egawa, Katsuya; M. Sharma, Prem; M. Olefsky, Jerrold; Kobayashi, Masashi

doi:10.1210/mend.14.6.0446

Public

A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

Published in Molecular Endocrinology • Jun 1, 2000

Authors:

Tetsuro Haruta

Tatsuhito Uno

Junko Kawahara

Abstract

Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology 2 domain containing signaling molecules that mediate many of the pleiotropic actions of insulin. Insulin stimulation elicits serine/threonine phosphorylation of IRS-1, whi...

Subject

Insulin receptor

Insulin receptor substrate

IRS1

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