Decreased extra-renal urate excretion is a common cause of hyperuricemia

Ichida, Kimiyoshi; Matsuo, Hirotaka; Takada, Tappei; Nakayama, Akiyoshi; Murakami, Keizo; Shimizu, Toru; Yamanashi, Yoshihide; Kasuga, Hiroshi; Nakashima, Hiroshi; Nakamura, Takahiro; Takada, Yuzo; Kawamura, Yusuke; Inoue, Hiroki; Okada, Chisa; Utsumi, Yoshitaka; Ikebuchi, Yuki; Ito, Kousei; Nakamura, Makiko; Shinohara, Yoshihiko; Hosoyamada, Makoto; Sakurai, Yutaka; Shinomiya, Nariyoshi; Hosoya, Tatsuo; Suzuki, Hiroshi

doi:10.1038/ncomms1756

Public

Decreased extra-renal urate excretion is a common cause of hyperuricemia

Published in Nature Communications • Apr 3, 2012

Authors:

Kimiyoshi Ichida

Hirotaka Matsuo

Tappei Takada

Abstract

ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal ...

Subject

Hyperuricemia

Gout

Internal medicine

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