Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Lim, Sharon; Yih Saw, Tzuen; Zhang, Min; R. Janes, Matthew; Nacro, Kassoum; Hill, Jeffrey; Qi Lim, An; Chang, Chia-Tien; A. Fruman, David; A. Rizzieri, David; Tan, Soo‐Yong; Fan, Hung; Chuah, Charles; Tiong Ong, S.

doi:10.1073/pnas.1301838110

Public

Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Published in Proceedings of the National Academy of Sciences • Jun 4, 2013

Authors:

Sharon Lim

Tzuen Yih Saw

Min Zhang

Abstract

Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein BCR-ABL1 in chronic phase, but is resistant to treatment after it progresses to blast crisis (BC). BC is characterized by elevated β-catenin signaling in granulocyte macrophage progenitors (GMPs), which enables ...

Subject

Myeloid leukemia

Stem cell

Cancer research

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