3-Aryl-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration.

B, Joseph; F, Darro; A, Béhard; B, Lesur; F, Collignon; C, Decaestecker; A, Frydman; G, Guillaumet; R, Kiss

doi:10.1021/jm010978m

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3-Aryl-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration.

Shared by NobleBlocks on Jun 1, 2002 • 12:00 AM UTC

Authors:

Joseph B

Darro F

Béhard A

Abstract

Among 25 3-aryl-2-quinolone derivatives synthesized, the antitumor activity of some of them was characterized both in vitro and in vivo. In this series, no compound appeared to be cytotoxic in vitro, as was known by the colorimetric MTT assay carried out on 12 distinct human cancer cell lines obtain...

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