The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.

A, Shavinskaya; S, Boulant; F, Penin; J, McLauchlan; R, Bartenschlager

doi:10.1074/jbc.m707329200

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The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.

Shared by NobleBlocks on Oct 17, 2007 • 12:00 AM UTC

Authors:

Shavinskaya A

Boulant S

Penin F

Abstract

Hepatitis C virus core protein forms the viral capsid and is targeted to lipid droplets (LDs) by its domain 2 (D2). By using a comparative analysis of two hepatitis C virus genomes (JFH1 and Jc1) differing in their level of virus production in cultured human hepatoma cells, we demonstrate that the c...

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