Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, Minsheng; Konstantopoulos, Nicky; Lee, Jongsoon; Hansen, Lone; Li, Zhiwei; Karin, Michael; E. Shoelson, Steven

doi:10.1126/science.1061620

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Published in Science • Aug 31, 2001

Authors:

Minsheng Yuan

Nicky Konstantopoulos

Jongsoon Lee

Abstract

We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression of the IkappaB kinase beta (IKKbeta) attenuated insulin signaling in cultured cells, whereas IKKbeta inhibition reversed in...

Subject

Insulin resistance

Hyperinsulinemia

IκB kinase

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