Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of
            <i>Ikkβ</i>

Yuan, Minsheng; Konstantopoulos, Nicky; Lee, Jongsoon; Hansen, Lone; Li, Zhi-Wei; Karin, Michael; E. Shoelson, Steven

doi:10.1126/science.1061620

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Shared by NobleBlocks on Aug 28, 2001 • 12:00 AM UTC

Authors:

Minsheng Yuan

Nicky Konstantopoulos

Jongsoon Lee

Abstract

We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression of the IκB kinase β (IKKβ) attenuated insulin signaling in cultured cells, whereas IKKβ inhibition reversed insulin resista...

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