Altered synaptic plasticity in a mouse model of fragile X mental retardation

M. Huber, Kimberly; Gallagher, Sean; T. Warren, Stephen; F. Bear, Mark

doi:10.1073/pnas.122205699

Public

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Published in Proceedings of the National Academy of Sciences • May 21, 2002

Authors:

Kimberly M. Huber

Sean Gallagher

Stephen T. Warren

Abstract

Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical evidence indicates that FMRP binds a subset of mRNAs and acts as a regulator of translation. However, the ...

Subject

Fragile X syndrome

FMR1

Metabotropic glutamate receptor

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!