Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration

Draganov, Dragomir; A. Markham, Dan; Beyer, D.; M. Waechter, John; S. Dimond, Stephen; A. Budinsky, Robert; N. Shiotsuka, Ronald; A. Snyder, Stephanie; Ehman, Kimberly; G. Hentges, Steven

doi:10.1016/j.tox.2015.04.012

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Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration

Published in Toxicology • Apr 27, 2015

Authors:

Dragomir Draganov

Dan A. Markham

D. Beyer

Abstract

Orally administered bisphenol A (BPA) undergoes efficient first-pass metabolism to produce the inactive conjugates BPA-glucuronide (BPA-G) and BPA-sulfate (BPA-S). This study was conducted to evaluate the pharmacokinetics of BPA, BPA-G and BPA-S in neonatal mice following the administration of a sin...

Subject

Pharmacokinetics

Oral administration

Bisphenol A

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