Genetic correction of PSA values using sequence variants associated with PSA levels.

Gudmundsson, Julius; Besenbacher, Soren; Sulem, Patrick; F Gudbjartsson, Daniel; Olafsson, Isleifur; Arinbjarnarson, Sturla; A Agnarsson, Bjarni; R Benediktsdottir, Kristrun; J Isaksson, Helgi; P Kostic, Jelena; A Gudjonsson, Sigurjon; N Stacey, Simon; Gylfason, Arnaldur; Sigurdsson, Asgeir; Holm, Hilma; S Bjornsdottir, Unnur; I Eyjolfsson, Gudmundur; Navarrete, Sebastian; Fuertes, Fernando; D Garcia-Prats, Maria; Polo, Eduardo; A Checherita, Ionel; Jinga, Mariana; Badea, Paula; K Aben, Katja; A Schalken, Jack; M van Oort, Inge; C Sweep, Fred; T Helfand, Brian; Davis, Michael; L Donovan, Jenny; C Hamdy, Freddie; Kristjansson, Kristleifur; R Gulcher, Jeffrey; Masson, Gisli; Kong, Augustine; J Catalona, William; I Mayordomo, Jose; Geirsson, Gudmundur; V Einarsson, Gudmundur; B Barkardottir, Rosa; Jonsson, Eirikur; Jinga, Viorel; Mates, Dana; A Kiemeney, Lambertus; E Neal, David; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Stefansson, Kari

doi:10.1126/scitranslmed.3001513

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Genetic correction of PSA values using sequence variants associated with PSA levels.

Shared by NobleBlocks on Dec 15, 2010 • 12:00 AM UTC

Authors:

Julius Gudmundsson

Soren Besenbacher

Patrick Sulem

Abstract

Measuring serum levels of the prostate-specific antigen (PSA) is the most common screening method for prostate cancer. However, PSA levels are affected by a number of factors apart from neoplasia. Notably, around 40% of the variability of PSA levels in the general population is accounted for by inhe...

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