Genetic Correction of PSA Values Using Sequence Variants Associated with PSA Levels

Guðmundsson, Jūlı́us; Besenbacher, Søren; Sulem, Patrick; F. Guðbjartsson, Daníel; Ólafsson, Ísleifur; Arinbjarnarson, Sturla; A. Agnarsson, Bjarni; R. Benediktsdóttir, Kristrún; J. Ísaksson, Helgi; P. Kostic, Jelena; A. Guðjónsson, Sigurjón; Stacey, Simon; Gylfason, Arnaldur; Sigurðsson, Ásgeir; Hólm, Hilma; Steina Björnsdóttir, Unnur; I. Eyjólfsson, Guðmundur; Navarrete, Sebastián; Fuertes, Fernando; Dolores García-Prats, María; Polo, Eduardo; Alexandru Checheriţă, Ionel; Jinga, Mariana; Badea, P; K.H. Aben, Katja; A. Schalken, Jack; M. van Oort, Inge; C.G.J. Sweep, Fred; T. Helfand, Brian; Davis, Michael; Donovan, Jenny; C. Hamdy, Freddie; Kristjánsson, Kristleifur; R. Gulcher, Jeffrey; Másson, Gísli; Kong, Augustine; J. Catàlona, William; Mayordomo, José; Geirsson, Guðmundur; Einarsson, Guðmundur; B. Barkardóttir, Rósa; Jónsson, Eiríkur; Jinga, Viorel; Mateș, Dana; A. Kiemeney, Lambertus; E. Neal, David; Þorsteinsdóttir, Unnur; Rafnar, Þórunn; Stefánsson, Kāri

doi:10.1126/scitranslmed.3001513

Public

Genetic Correction of PSA Values Using Sequence Variants Associated with PSA Levels

Published in Science Translational Medicine • Dec 15, 2010

Authors:

Jūlı́us Guðmundsson

Søren Besenbacher

Patrick Sulem

Abstract

Measuring serum levels of the prostate-specific antigen (PSA) is the most common screening method for prostate cancer. However, PSA levels are affected by a number of factors apart from neoplasia. Notably, around 40% of the variability of PSA levels in the general population is accounted for by inhe...

Subject

Sequence (biology)

Biology

Genetics

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