Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Nobukuni, Takahiro; Joaquin, Manel; Roccio, Marta; G. Dann, Stephen; Young Kim, So; Gulati, Pawan; Byfield, Maya; Backer, Jonathan; Natt, François; L. Bos, Johannes; Zwartkruis, Fried; Thomas, George

doi:10.1073/pnas.0506925102

Public

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Published in Proceedings of the National Academy of Sciences • Sep 21, 2005

Authors:

Takahiro Nobukuni

Manel Joaquin

Marta Roccio

Abstract

During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathway to control the growth and development of the org...

Subject

PI3K/AKT/mTOR pathway

Phosphatidylinositol

Amino acid

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