Impact of HIV-1 genetic diversity on plasma HIV-1 RNA Quantification: usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test.

F, Rouet; ML, Chaix; E, Nerrienet; N, Ngo-Giang-Huong; JC, Plantier; M, Burgard; M, Peeters; F, Damond; DK, Ekouevi; P, Msellati; L, Ferradini; S, Rukobo; V, Maréchal; N, Schvachsa; L, Wakrim; C, Rafalimanana; B, Rakotoambinina; JP, Viard; JM, Seigneurin; C, Rouzioux

doi:10.1097/qai.0b013e3180640cf5

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Impact of HIV-1 genetic diversity on plasma HIV-1 RNA Quantification: usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test.

Shared by NobleBlocks on Aug 1, 2007 • 12:00 AM UTC

Authors:

Rouet F

Chaix ML

Nerrienet E

Abstract

The high genetic diversity of HIV-1 has a major impact on the quantification of plasma HIV-1 RNA, representing an increasingly difficult challenge. A total of 898 plasma specimens positive for HIV-1 RNA by commercial assays (Amplicor v1.5; Roche Diagnostic Systems, Alameda, CA or Versant v3.0; Bayer...

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