Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

E. Paleologou, Katerina; W. Schmid, Adrien; C. Rospigliosi, Carla; Kim, Hai‐Young; R. Lamberto, Gonzalo; A. Fredenburg, Ross; T. Lansbury, Peter; O. Fernández, Claudio; Eliezer, David; Zweckstetter, Markus; A. Lashuel, Hilal

doi:10.1074/jbc.m800747200

Public

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

Published in Journal of Biological Chemistry • Mar 15, 2008

Authors:

Katerina E. Paleologou

Adrien W. Schmid

Carla C. Rospigliosi

Abstract

α-Synuclein (α-syn) phosphorylation at serine 129 is characteristic of Parkinson disease (PD) and related α-synulceinopathies. However, whether phosphorylation promotes or inhibits α-syn aggregation and neurotoxicity in vivo remains unknown. This understanding is critical for elucidating the role of...

Subject

Phosphorylation

Alpha-synuclein

Fibrillogenesis

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!