Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes

Liu, Huifang; Zhang, Huijie; Hu, Qi-Xian; Liu, Xiaoyan; Wang, Zhiquan; Fan, Jiayan; Zhan, Ming; Chen, Fengling

doi:10.1155/2012/867023

Public

Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes

Published in BioMed Research International • Jan 1, 2012

Authors:

Huifang Liu

Huijie Zhang

Qi-Xian Hu

Abstract

Type 2 diabetes (T2D) is associated with perturbed innate immunity. Macrophages, bridging innate immunity and metabolic disturbances, play important roles in controlling immune homeostasis. However, the effect of long-term diabetic milieu (DM) on the functions and phenotypes of macrophages is still ...

Subject

Innate immune system

Phagocytosis

Immunity

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