Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Brem, Henry; Piantadosi, Steven; C. Burger, P.; Walker, Melissa; G. Selker, Robert; A. Vick, Nicholas; L. Black, Keith; B. Sisti, Michael; Brem, Steven; Mohr, Gérard; Muller, P; B. Morawetz, Richard; Clifford Schold, S.

doi:10.1016/s0140-6736(95)90755-6

Public

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Published in The Lancet • Apr 1, 1995

Authors:

Henry Brem

Steven Piantadosi

P. C. Burger

Abstract

Chemotherapy for brain tumours has been limited because of difficulty in achieving adequate exposure to the tumour without systemic toxicity. We have developed a method for local sustained release of chemotherapeutic agents by their incorporation into biodegradable polymers. Implantation of the drug...

Subject

Carmustine

Medicine

Chemotherapy

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