BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

Davies, Rachel; Holmes, Alan; Deighton, John; Long, Lü; Yang, Xudong; Barker, Lucy; Walker, Christoph; C. Budd, David; D. Upton, Paul; W. Morrell, Nicholas

doi:10.1152/ajplung.00309.2011

Public

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

Published in American Journal of Physiology-Lung Cellular and Molecular Physiology • Jan 7, 2012

Authors:

Rachel Davies

Alan Holmes

John Deighton

Abstract

Mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR-II) underlie most cases of heritable pulmonary arterial hypertension (HPAH) and a significant proportion of sporadic cases. Pulmonary artery smooth muscle cells (PASMCs) from patients with pulmonary arterial hypertension (PAH) ...

Subject

SMAD

Transforming growth factor

BMPR2

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