Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy

Bouchard, Luigi; Thibault, Stéphanie; Guay, Simon‐Pierre; Santuré, Marta; Monpetit, Alexandre; St‐Pierre, Julie; Perron, Patrice; Brisson, Diane

doi:10.2337/dc10-1024

Public

Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy

Published in Diabetes Care • Aug 19, 2010

Authors:

Luigi Bouchard

Stéphanie Thibault

Simon‐Pierre Guay

Abstract

OBJECTIVE: To verify whether the leptin gene epigenetic (DNA methylation) profile is altered in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: Placental tissues and maternal and cord blood samples were obtained from 48 women at term including...

Subject

Leptin

Endocrinology

Internal medicine

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