Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

Crettol, Séverine; Déglon, Julien; Besson, Jacques; CROQUETTEKROKKAR, M; Gothuey, Isabelle; Hämmig, Robert; Monnat, Martine; HUTTEMANN, H; Baumann, Pierre; B. Eap, Chin

doi:10.1016/j.clpt.2005.08.011

Public

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

Published in Clinical Pharmacology & Therapeutics • Dec 1, 2005

Authors:

Séverine Crettol

Julien Déglon

Jacques Besson

Abstract

BACKGROUND AND OBJECTIVE: Recent in vitro studies have suggested an important role of cytochrome P450 (CYP) 2B6 and CYP2C19 in methadone metabolism. We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment....

Subject

CYP2B6

CYP2C9

CYP2C19

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