Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kimura, Kazushi; Ito, Masaaki; Amano, Mutsuki; Chihara, Kazuyasu; Fukata, Yuko; Nakafuku, Masato; Yamamori, Bunpei; Feng, Jianhua; Nakano, Takeshi; Okawa, Katsuya; Iwamatsu, Akihiro; Kaibuchi, Kozo

doi:10.1126/science.273.5272.245

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Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Published in Science • Jul 12, 1996

Authors:

Kazushi Kimura

Masaaki Ito

Mutsuki Amano

Abstract

The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with ...

Subject

RHOA

Myosin

Rho-associated protein kinase

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