Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Excessive cerebral accumulation of the 42-residue amyloid beta-protein (Abeta) is an early and invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the cellular production of Abeta from its membrane-bound precursor, including the role of the presenilin proteins there... View More