2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

T, Maruyama; T, Kanaji; S, Nakade; T, Kanno; K, Mikoshiba

doi:10.1093/oxfordjournals.jbchem.a021780

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2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

Shared by NobleBlocks on Sep 1, 1997 • 12:00 AM UTC

Authors:

Maruyama T

Kanaji T

Nakade S

Abstract

The effects of a novel membrane-penetrable modulator, 2APB (2-aminoethoxy diphenyl borate), on Ins(1,4,5)P3-induced Ca2+ release were examined. 2APB inhibited Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations without affecting [3H]Ins(1,4,5)P3 binding to its receptor. The...

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