Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

T. Weirauch, Matthew; Yang, Ally; Albu, Mihai; G. Coté, Atina; Montenegro‐Montero, Alejandro; Drewe, Philipp; S. Najafabadi, Hamed; A. Lambert, Samuel; K. Mann, Ishminder; B. Cook, Kate; Zheng, Hong; Goity, Alejandra; van Bakel, Harm; Lozano, Jean-Claude; Galli, Mary; G. Lewsey, Mathew; Huang, Eryong; Mukherjee, Tuhin; Chen, Xiaoting; Reece-Hoyes, John; Govindarajan, Sridhar; Shaulsky, Gad; J.M. Walhout, Albertha; Bouget, François-Yves; Rätsch, Gunnar; Larrondo, Luis; R. Ecker, Joseph; R. Hughes, Timothy

doi:10.1016/j.cell.2014.08.009

Public

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

Published in Cell • Sep 1, 2014

Authors:

Matthew T. Weirauch

Ally Yang

Mihai Albu

Abstract

Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are currently known for only ∼1% of eukaryotic TFs. Broadly sampling DNA-binding domain (DBD) types from multiple eukaryotic clades, we determined DNA sequence preferences for >1,000 TFs encompassing 54 differen...

Subject

Biology

Inference

Computational biology

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